![]() ![]() Therefore, understanding how signal-responsive TFs are integrated into a dynamic cellular context will further our knowledge of the mechanisms guiding the acquisition of specific cellular identities. The effect of a signal on gene expression, and ultimately on cell fate, depends on where such TFs bind to the genome. While these external signals can take the form of steroid hormones, protein growth factors, or other molecules, their presence is typically communicated by signal-responsive transcription factors (TFs). Cellular competence, fate determination, and differentiation are influenced by the external signals cells receive. ![]()
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